Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model

Mutations in the nuclear structural protein lamin A produce rare, tissue-specific diseases called laminopathies. The introduction of a human Emery-Dreifuss muscular dystrophy (EDMD)-inducing mutation into the C. elegans lamin (LMN-Y59C), recapitulates many muscular dystrophy phenotypes, and correlat...

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Detalles Bibliográficos
Autores principales: Harr, Jennifer C., Schmid, Christoph D., Muñoz-Jiménez, Celia, Romero-Bueno, Raquel, Kalck, Véronique, Gonzalez-Sandoval, Adriana, Hauer, Michael H., Padeken, Jan, Askjaer, Peter, Mattout, Anna, Gasser, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111258/
https://www.ncbi.nlm.nih.gov/pubmed/32139421
http://dx.doi.org/10.1101/gad.332213.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111258/
https://www.ncbi.nlm.nih.gov/pubmed/32139421
http://dx.doi.org/10.1101/gad.332213.119

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