The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice

Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that following partial hepatectomy, the senescence-associated genes p21, p16(Ink4a), an...

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Detalles Bibliográficos
Autores principales: Ritschka, Birgit, Knauer-Meyer, Tania, Gonçalves, Daniel Sampaio, Mas, Alba, Plassat, Jean-Luc, Durik, Matej, Jacobs, Hugues, Pedone, Elisa, Di Vicino, Umberto, Cosma, Maria Pia, Keyes, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111259/
https://www.ncbi.nlm.nih.gov/pubmed/32139422
http://dx.doi.org/10.1101/gad.332643.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111259/
https://www.ncbi.nlm.nih.gov/pubmed/32139422
http://dx.doi.org/10.1101/gad.332643.119

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