Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides

A focused nucleoside library was constructed around a 3′-C-ethynyl-d-ribofuranose sugar scaffold, which was coupled to variously modified purine nucleobases. The resulting nucleosides were probed for their ability to inhibit tumor cell proliferation, as well as for their activity against a panel of...

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Detalles Bibliográficos
Autores principales: Hulpia, Fabian, Noppen, Sam, Schols, Dominique, Andrei, Graciela, Snoeck, Robert, Liekens, Sandra, Vervaeke, Peter, Van Calenbergh, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111280/
https://www.ncbi.nlm.nih.gov/pubmed/30098481
http://dx.doi.org/10.1016/j.ejmech.2018.07.062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111280/
https://www.ncbi.nlm.nih.gov/pubmed/30098481
http://dx.doi.org/10.1016/j.ejmech.2018.07.062

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