Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus

Cavally virus (CavV) is a mosquito-borne plus-strand RNA virus in the family Mesoniviridae (order Nidovirales). We present X-ray structures for the CavV 3C-like protease (3CL(pro)), as a free enzyme and in complex with a peptide aldehyde inhibitor mimicking the P4-to-P1 residues of a natural substra...

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Detalles Bibliográficos
Autores principales: Kanitz, Manuel, Blanck, Sandra, Heine, Andreas, Gulyaeva, Anastasia A., Gorbalenya, Alexander E., Ziebuhr, John, Diederich, Wibke E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111312/
https://www.ncbi.nlm.nih.gov/pubmed/31078932
http://dx.doi.org/10.1016/j.virol.2019.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111312/
https://www.ncbi.nlm.nih.gov/pubmed/31078932
http://dx.doi.org/10.1016/j.virol.2019.05.001

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