Design and synthesis of a series of serine derivatives as small molecule inhibitors of the SARS coronavirus 3CL protease

Synthesis of serine derivatives having the essential functional groups for the inhibitor of SARS 3CL protease and evaluation of their inhibitory activities using SARS 3CL R188I mutant protease are described. The lead compounds, functionalized serine derivatives, were designed based on the tetrapepti...

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Detalles Bibliográficos
Autores principales: Konno, Hiroyuki, Wakabayashi, Masaki, Takanuma, Daiki, Saito, Yota, Akaji, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111485/
https://www.ncbi.nlm.nih.gov/pubmed/26879854
http://dx.doi.org/10.1016/j.bmc.2016.01.052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111485/
https://www.ncbi.nlm.nih.gov/pubmed/26879854
http://dx.doi.org/10.1016/j.bmc.2016.01.052

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