Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism

We previously characterized a foot-and-mouth disease virus (FMDV) with three amino acid replacements in its polymerase (3D) that conferred resistance to the mutagenic nucleoside analogue ribavirin. Here we show that passage of this mutant in the presence of high ribavirin concentrations resulted in...

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Detalles Bibliográficos
Autores principales: Agudo, Rubén, de la Higuera, Ignacio, Arias, Armando, Grande-Pérez, Ana, Domingo, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111656/
https://www.ncbi.nlm.nih.gov/pubmed/27136067
http://dx.doi.org/10.1016/j.virol.2016.04.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111656/
https://www.ncbi.nlm.nih.gov/pubmed/27136067
http://dx.doi.org/10.1016/j.virol.2016.04.023

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