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Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism
We previously characterized a foot-and-mouth disease virus (FMDV) with three amino acid replacements in its polymerase (3D) that conferred resistance to the mutagenic nucleoside analogue ribavirin. Here we show that passage of this mutant in the presence of high ribavirin concentrations resulted in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111656/ https://www.ncbi.nlm.nih.gov/pubmed/27136067 http://dx.doi.org/10.1016/j.virol.2016.04.023 |