Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells

The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine is described allowing for selective manipulation of the 1,2-hydroxyl groups. A mini-library comprised of synthetic and natural lycorane alkaloids was prepared and th...

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Detalles Bibliográficos
Autores principales: McNulty, James, Nair, Jerald J., Bastida, Jaume, Pandey, Siyaram, Griffin, Carly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111684/
https://www.ncbi.nlm.nih.gov/pubmed/19464034
http://dx.doi.org/10.1016/j.phytochem.2009.04.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111684/
https://www.ncbi.nlm.nih.gov/pubmed/19464034
http://dx.doi.org/10.1016/j.phytochem.2009.04.012

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