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Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells
The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine is described allowing for selective manipulation of the 1,2-hydroxyl groups. A mini-library comprised of synthetic and natural lycorane alkaloids was prepared and th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111684/ https://www.ncbi.nlm.nih.gov/pubmed/19464034 http://dx.doi.org/10.1016/j.phytochem.2009.04.012 |