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Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive

All RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which in arteriviruses is expressed as the C-terminal domain of nonstructural protein 9 (nsp9). Previously, potent primer-dependent RdRp activity has been demonstrated for the homologous polymerase subunit (nsp12) of the distantly relate...

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Detalles Bibliográficos
Autores principales: Lehmann, Kathleen C., Gorbalenya, Alexander E., Snijder, Eric J., Posthuma, Clara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111705/
https://www.ncbi.nlm.nih.gov/pubmed/26499043
http://dx.doi.org/10.1016/j.virol.2015.10.002