Synthesis of fluorinated acyclic nucleoside phosphonates with 5-azacytosine base moiety

With respect to the strong antiviral activity of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine various types of its side chain fluorinated analogues were prepared. The title compound, (S)-1-[3-fluoro-2-(phosphonomethoxy)propyl]-5-azacytosine (FPMP-5-azaC) was synthesised by the condensa...

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Detalles Bibliográficos
Autores principales: Pomeisl, Karel, Krečmerová, Marcela, Pohl, Radek, Snoeck, Robert, Andrei, Graciela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111758/
https://www.ncbi.nlm.nih.gov/pubmed/32287433
http://dx.doi.org/10.1016/j.tet.2019.130529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111758/
https://www.ncbi.nlm.nih.gov/pubmed/32287433
http://dx.doi.org/10.1016/j.tet.2019.130529

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