Diastereoselective synthesis of 2-fluoroaziridine-2-carboxylates by Reformatsky-type aza-Darzens reaction

The reaction of ethyl dibromofluoroacetate with imines using zinc metal gave 2-fluoroaziridine-2-carboxylates via aza-Darzens reaction of the primary product of the Reformatsky reaction with high diastereoselectivity in excellent yields (quantitative yield and Dr = 85:15). This chemoselective format...

Descripción completa

Detalles Bibliográficos
Autores principales: Tarui, Atsushi, Kawashima, Naoto, Sato, Kazuyuki, Omote, Masaaki, Ando, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111781/
https://www.ncbi.nlm.nih.gov/pubmed/32287441
http://dx.doi.org/10.1016/j.tetlet.2010.06.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111781/
https://www.ncbi.nlm.nih.gov/pubmed/32287441
http://dx.doi.org/10.1016/j.tetlet.2010.06.030

Ejemplares similares