Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication

All coronaviruses encode a small hydrophobic envelope (E) protein, which mediates viral assembly and morphogenesis by an unknown mechanism. We have previously shown that the E protein from Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) forms cation-selective ion channels in planar lipid bi...

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Detalles Bibliográficos
Autores principales: Wilson, Lauren, Gage, Peter, Ewart, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111787/
https://www.ncbi.nlm.nih.gov/pubmed/16815524
http://dx.doi.org/10.1016/j.virol.2006.05.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111787/
https://www.ncbi.nlm.nih.gov/pubmed/16815524
http://dx.doi.org/10.1016/j.virol.2006.05.028

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