Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors

Trifluoromethyl-β-amino alcohol 11 [(4S)-tert-butyl 4-amino-6,6,6-trifluoro-5-hydroxyhexanoate] was synthesized in five steps starting from Cbz-l-Glu-OH 5 where the key step involved the introduction of the trifluoromethyl (CF(3)) group to oxazolidinone 7, resulting in the formation of silyl ether 8...

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Detalles Bibliográficos
Autores principales: Sydnes, Magne O., Hayashi, Yoshio, Sharma, Vinay K., Hamada, Takashi, Bacha, Usman, Barrila, Jennifer, Freire, Ernesto, Kiso, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111793/
https://www.ncbi.nlm.nih.gov/pubmed/32287416
http://dx.doi.org/10.1016/j.tet.2006.06.052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111793/
https://www.ncbi.nlm.nih.gov/pubmed/32287416
http://dx.doi.org/10.1016/j.tet.2006.06.052

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