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Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein

A secreted, glycosylated polypeptide containing amino acids 14 to 762 of the SARS coronavirus (SARS-CoV) spike protein and a polyhistidine tag was expressed in recombinant baculovirus-infected insect cells. Mice received the affinity-purified protein with either a saponin (QS21) or a Ribi (MPL + TDM...

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Detalles Bibliográficos
Autores principales:	Bisht, Himani, Roberts, Anjeanette, Vogel, Leatrice, Subbarao, Kanta, Moss, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111832/ https://www.ncbi.nlm.nih.gov/pubmed/15780866 http://dx.doi.org/10.1016/j.virol.2005.01.042

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