A regioselective etherification of pyridoxine via an ortho-pyridinone methide intermediate

The catalyst-free, regioselective synthesis of 4′-O-substituted pyridoxine derivatives under solventless conditions is described. The methodology relies on the highly regioselective formation of the ortho-pyridinone methide from pyridoxine and subsequent oxa-Michael addition of alcohol nucleophiles....

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Detalles Bibliográficos
Autores principales: Yazarians, Jessica A., Jiménez, Brian L., Boyce, Gregory R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111860/
https://www.ncbi.nlm.nih.gov/pubmed/32287448
http://dx.doi.org/10.1016/j.tetlet.2017.04.082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111860/
https://www.ncbi.nlm.nih.gov/pubmed/32287448
http://dx.doi.org/10.1016/j.tetlet.2017.04.082

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