An arginine-to-proline mutation in a domain with undefined functions within the helicase protein (Nsp13) is lethal to the coronavirus infectious bronchitis virus in cultured cells

Genetic manipulation of the RNA genomes by reverse genetics is a powerful tool to study the molecular biology and pathogenesis of RNA viruses. During construction of an infectious clone from a Vero cell-adapted coronavirus infectious bronchitis virus (IBV), we found that a G–C point mutation at nucl...

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Detalles Bibliográficos
Autores principales: Fang, Shouguo, Chen, Bo, Tay, Felicia P.L., Ng, Beng Sern, Liu, Ding Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111978/
https://www.ncbi.nlm.nih.gov/pubmed/16979681
http://dx.doi.org/10.1016/j.virol.2006.08.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111978/
https://www.ncbi.nlm.nih.gov/pubmed/16979681
http://dx.doi.org/10.1016/j.virol.2006.08.020

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