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Cyclophilins and cyclophilin inhibitors in nidovirus replication

Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs, which can also block the replication of nidoviruses (arteriviruses and coronav...

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Detalles Bibliográficos
Autores principales: de Wilde, Adriaan H., Pham, Uyen, Posthuma, Clara C., Snijder, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112023/
https://www.ncbi.nlm.nih.gov/pubmed/30014857
http://dx.doi.org/10.1016/j.virol.2018.06.011