Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase

The severe acute respiratory syndrome (SARS) virus depends on a chymotrypsin-like cysteine proteinase (3CL(pro)) to process the translated polyproteins to functional viral proteins. This enzyme is a target for the design of potential anti-SARS drugs. A series of ketones and corresponding mono- and d...

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Detalles Bibliográficos
Autores principales: Zhang, Jianmin, Huitema, Carly, Niu, Chunying, Yin, Jiang, James, Michael N.G., Eltis, Lindsay D., Vederas, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112044/
https://www.ncbi.nlm.nih.gov/pubmed/18295820
http://dx.doi.org/10.1016/j.bioorg.2008.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112044/
https://www.ncbi.nlm.nih.gov/pubmed/18295820
http://dx.doi.org/10.1016/j.bioorg.2008.01.001

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