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Lipidation increases antiviral activities of coronavirus fusion-inhibiting peptides

Coronaviruses (CoVs) can cause life-threatening respiratory diseases. Their infectious entry requires viral spike (S) proteins, which attach to cell receptors, undergo proteolytic cleavage, and then refold in a process that catalyzes virus-cell membrane fusion. Fusion-inhibiting peptides bind to S p...

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Detalles Bibliográficos
Autores principales: Park, Jung-Eun, Gallagher, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112077/
https://www.ncbi.nlm.nih.gov/pubmed/28802158
http://dx.doi.org/10.1016/j.virol.2017.07.033