SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses

Viruses possessing class I fusion proteins require proteolytic activation by host cell proteases to mediate fusion with the host cell membrane. The mammalian SPINT2 gene encodes a protease inhibitor that targets trypsin-like serine proteases. Here we show the protease inhibitor, SPINT2, restricts cl...

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Detalles Bibliográficos
Autores principales: Straus, Marco R., Kinder, Jonathan T., Segall, Michal, Dutch, Rebecca Ellis, Whittaker, Gary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112099/
https://www.ncbi.nlm.nih.gov/pubmed/32056846
http://dx.doi.org/10.1016/j.virol.2020.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112099/
https://www.ncbi.nlm.nih.gov/pubmed/32056846
http://dx.doi.org/10.1016/j.virol.2020.01.004

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