Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites

Trypanosoma cruzi parasites utilise de novo pyrimidine biosynthesis to produce DNA and survive within mammalian host cells. This pathway can be hijacked to assess the replication of intracellular parasites with the exogenous addition of a DNA specific probe. To identify suitable probe compounds for...

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Detalles Bibliográficos
Autores principales: Sykes, Melissa Louise, Hilko, David Hugh, Kung, Livia Isabella, Poulsen, Sally-Ann, Avery, Vicky Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112222/
https://www.ncbi.nlm.nih.gov/pubmed/32163414
http://dx.doi.org/10.1371/journal.pntd.0008068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112222/
https://www.ncbi.nlm.nih.gov/pubmed/32163414
http://dx.doi.org/10.1371/journal.pntd.0008068

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