Development of robust in vitro RNA-dependent RNA polymerase assay as a possible platform for antiviral drug testing against dengue

NS5 is the largest and most conserved protein among the four dengue virus (DENV) serotypes. It has been the target of interest for antiviral drug development due to its major role in replication. NS5 consists of two domains, the N-terminal methyltransferase domain and C-terminal catalytic RNA-depend...

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Detalles Bibliográficos
Autores principales: Amraiz, Deeba, Zaidi, Najam-us-Sahar Sadaf, Fatima, Munazza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112394/
https://www.ncbi.nlm.nih.gov/pubmed/27542741
http://dx.doi.org/10.1016/j.enzmictec.2016.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112394/
https://www.ncbi.nlm.nih.gov/pubmed/27542741
http://dx.doi.org/10.1016/j.enzmictec.2016.06.010

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