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Development of robust in vitro RNA-dependent RNA polymerase assay as a possible platform for antiviral drug testing against dengue
NS5 is the largest and most conserved protein among the four dengue virus (DENV) serotypes. It has been the target of interest for antiviral drug development due to its major role in replication. NS5 consists of two domains, the N-terminal methyltransferase domain and C-terminal catalytic RNA-depend...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112394/ https://www.ncbi.nlm.nih.gov/pubmed/27542741 http://dx.doi.org/10.1016/j.enzmictec.2016.06.010 |