B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response

Activation-induced cytidine deaminase (AID) mediates immunoglobulin class switch DNA recombination (CSR) and somatic hypermutation (SHM), critical processes for maturation of the antibody response. Epigenetic factors, such as histone deacetylases (HDACs), would underpin B cell differentiation stage–...

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Detalles Bibliográficos
Autores principales: Gan, Huoqun, Shen, Tian, Chupp, Daniel P., Taylor, Julia R., Sanchez, Helia N., Li, Xin, Xu, Zhenming, Zan, Hong, Casali, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112761/
https://www.ncbi.nlm.nih.gov/pubmed/32270032
http://dx.doi.org/10.1126/sciadv.aay2793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112761/
https://www.ncbi.nlm.nih.gov/pubmed/32270032
http://dx.doi.org/10.1126/sciadv.aay2793

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