The attenuation of vaccinia Tian Tan strain by the removal of the viral M1L-K2L genes

To generate a safe vaccinia Tian Tan (VTT)-based vaccine vector, it is necessary to develop a method to attenuate the virus. A modified VTT (MVTT(2-GFP)) was constructed by replacing the viral M1L-K2L genes with a GFP gene. In comparison to the parental VTT, MVTT(2-GFP) lost its replication capacity...

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Detalles Bibliográficos
Autores principales: Zhu, Weijun, Fang, Qing, Zhuang, Ke, Wang, Haibo, Yu, Wenbo, Zhou, Jingying, Liu, Li, Tien, Po, Zhang, Linqi, Chen, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112875/
https://www.ncbi.nlm.nih.gov/pubmed/17459491
http://dx.doi.org/10.1016/j.jviromet.2007.03.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112875/
https://www.ncbi.nlm.nih.gov/pubmed/17459491
http://dx.doi.org/10.1016/j.jviromet.2007.03.012

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