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Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome

RIG-I and MDA5 receptors are key sensors of pathogen-associated molecular pattern (PAMP)-containing viral RNA and transduce downstream signals to activate an antiviral and immunomodulatory response. Fifteen years of research have put them at the center of an ongoing hunt for novel pharmacological pa...

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Detalles Bibliográficos
Autores principales: Kasumba, Dacquin M., Grandvaux, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112877/
https://www.ncbi.nlm.nih.gov/pubmed/30606502
http://dx.doi.org/10.1016/j.tips.2018.12.003