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Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome
RIG-I and MDA5 receptors are key sensors of pathogen-associated molecular pattern (PAMP)-containing viral RNA and transduce downstream signals to activate an antiviral and immunomodulatory response. Fifteen years of research have put them at the center of an ongoing hunt for novel pharmacological pa...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Ltd.
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112877/ https://www.ncbi.nlm.nih.gov/pubmed/30606502 http://dx.doi.org/10.1016/j.tips.2018.12.003 |