Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation

Mechanical forces play important roles in development, physiology, and diseases, but how force is transduced into gene transcription remains elusive. Here, we show that transcription of transgene DHFR or endogenous genes egr-1 and Cav1 is rapidly up-regulated in response to cyclic forces applied via...

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Detalles Bibliográficos
Autores principales: Sun, Jian, Chen, Junwei, Mohagheghian, Erfan, Wang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112933/
https://www.ncbi.nlm.nih.gov/pubmed/32270037
http://dx.doi.org/10.1126/sciadv.aay9095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112933/
https://www.ncbi.nlm.nih.gov/pubmed/32270037
http://dx.doi.org/10.1126/sciadv.aay9095

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