Cargando…
Role of IFN-γ responsiveness in CD8 T cell-mediated viral clearance and demyelination in coronavirus-infected mice
Immunocompetent, but not RAG1(−/−) mice infected with MHV–JHM develop demyelination. Transferred CD8 T cell-enriched splenocytes reconstitute demyelination, and this ability is dependent on donor IFN-γ. We used IFN-γR1(−/−) mice to examine the target of IFN-γ in CD8 T cell-mediated demyelination. In...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2008
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112937/ https://www.ncbi.nlm.nih.gov/pubmed/18082272 http://dx.doi.org/10.1016/j.jneuroim.2007.10.030 |