A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins. ClpXP is an important target for drug development against infectious diseases. Although structures are...

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Detalles Bibliográficos
Autores principales: Ripstein, Zev A, Vahidi, Siavash, Houry, Walid A, Rubinstein, John L, Kay, Lewis E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112952/
https://www.ncbi.nlm.nih.gov/pubmed/31916936
http://dx.doi.org/10.7554/eLife.52158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112952/
https://www.ncbi.nlm.nih.gov/pubmed/31916936
http://dx.doi.org/10.7554/eLife.52158

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