LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility

Heterozygous loss of human PAFAH1B1 (coding for LIS1) results in the disruption of neurogenesis and neuronal migration via dysregulation of microtubule (MT) stability and dynein motor function/localization that alters mitotic spindle orientation, chromosomal segregation, and nuclear migration. Recen...

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Detalles Bibliográficos
Autores principales: Moon, Hyang Mi, Hippenmeyer, Simon, Luo, Liqun, Wynshaw-Boris, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112955/
https://www.ncbi.nlm.nih.gov/pubmed/32159512
http://dx.doi.org/10.7554/eLife.51512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112955/
https://www.ncbi.nlm.nih.gov/pubmed/32159512
http://dx.doi.org/10.7554/eLife.51512

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