Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology

BACKGROUND: Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are putative, minimally invasive biomarkers of DMD. Specific ex‐miRNAs (e.g. miR‐1, miR‐133a, miR‐206, and miR‐483) are highly up‐regulat...

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Detalles Bibliográficos
Autores principales: van Westering, Tirsa L.E., Lomonosova, Yulia, Coenen‐Stass, Anna M.L., Betts, Corinne A., Bhomra, Amarjit, Hulsker, Margriet, Clark, Lucy E., McClorey, Graham, Aartsma‐Rus, Annemieke, van Putten, Maaike, Wood, Matthew J.A., Roberts, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113513/
https://www.ncbi.nlm.nih.gov/pubmed/31849191
http://dx.doi.org/10.1002/jcsm.12506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113513/
https://www.ncbi.nlm.nih.gov/pubmed/31849191
http://dx.doi.org/10.1002/jcsm.12506

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