Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes

Over 18 million disease cases and half a million deaths worldwide are estimated to be caused annually by Group A Streptococcus. A vaccine to prevent GAS disease is urgently needed. SpyCEP (Streptococcus pyogenes Cell-Envelope Proteinase) is a surface-exposed serine protease that inactivates chemokin...

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Detalles Bibliográficos
Autores principales: McKenna, Sophie, Malito, Enrico, Rouse, Sarah L., Abate, Francesca, Bensi, Giuliano, Chiarot, Emiliano, Micoli, Francesca, Mancini, Francesca, Gomes Moriel, Danilo, Grandi, Guido, Mossakowska, Danuta, Pearson, Max, Xu, Yingqi, Pease, James, Sriskandan, Shiranee, Margarit, Immaculada, Bottomley, Matthew J., Matthews, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113628/
https://www.ncbi.nlm.nih.gov/pubmed/32257048
http://dx.doi.org/10.1016/j.csbj.2020.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113628/
https://www.ncbi.nlm.nih.gov/pubmed/32257048
http://dx.doi.org/10.1016/j.csbj.2020.03.004

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