Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface

The PB1 C-terminal domain and PB2 N-terminal domain interaction of the influenza A polymerase, which modulates the assembly of PB1 and PB2 subunits, may serve as a valuable target for the development of novel anti-influenza therapeutics. In this study, we performed a systematic screening of a chemic...

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Detalles Bibliográficos
Autores principales: Yuan, Shuofeng, Chu, Hin, Ye, Jiahui, Singh, Kailash, Ye, Ziwei, Zhao, Hanjun, Kao, Richard Y.T., Chow, Billy K.C., Zhou, Jie, Zheng, Bo-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113721/
https://www.ncbi.nlm.nih.gov/pubmed/27840201
http://dx.doi.org/10.1016/j.antiviral.2016.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113721/
https://www.ncbi.nlm.nih.gov/pubmed/27840201
http://dx.doi.org/10.1016/j.antiviral.2016.11.005

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