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Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface
The PB1 C-terminal domain and PB2 N-terminal domain interaction of the influenza A polymerase, which modulates the assembly of PB1 and PB2 subunits, may serve as a valuable target for the development of novel anti-influenza therapeutics. In this study, we performed a systematic screening of a chemic...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113721/ https://www.ncbi.nlm.nih.gov/pubmed/27840201 http://dx.doi.org/10.1016/j.antiviral.2016.11.005 |