Emodin inhibits current through SARS-associated coronavirus 3a protein

The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit vi...

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Detalles Bibliográficos
Autores principales: Schwarz, Silvia, Wang, Kai, Yu, Wenjing, Sun, Bing, Schwarz, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114100/
https://www.ncbi.nlm.nih.gov/pubmed/21356245
http://dx.doi.org/10.1016/j.antiviral.2011.02.008
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author Schwarz, Silvia
Wang, Kai
Yu, Wenjing
Sun, Bing
Schwarz, Wolfgang
author_facet Schwarz, Silvia
Wang, Kai
Yu, Wenjing
Sun, Bing
Schwarz, Wolfgang
author_sort Schwarz, Silvia
collection PubMed
description The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K(1/2) value of about 20 μM. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents.
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spelling pubmed-71141002020-04-02 Emodin inhibits current through SARS-associated coronavirus 3a protein Schwarz, Silvia Wang, Kai Yu, Wenjing Sun, Bing Schwarz, Wolfgang Antiviral Res Article The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K(1/2) value of about 20 μM. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents. Elsevier B.V. 2011-04 2011-02-26 /pmc/articles/PMC7114100/ /pubmed/21356245 http://dx.doi.org/10.1016/j.antiviral.2011.02.008 Text en Copyright © 2011 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Schwarz, Silvia
Wang, Kai
Yu, Wenjing
Sun, Bing
Schwarz, Wolfgang
Emodin inhibits current through SARS-associated coronavirus 3a protein
title Emodin inhibits current through SARS-associated coronavirus 3a protein
title_full Emodin inhibits current through SARS-associated coronavirus 3a protein
title_fullStr Emodin inhibits current through SARS-associated coronavirus 3a protein
title_full_unstemmed Emodin inhibits current through SARS-associated coronavirus 3a protein
title_short Emodin inhibits current through SARS-associated coronavirus 3a protein
title_sort emodin inhibits current through sars-associated coronavirus 3a protein
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114100/
https://www.ncbi.nlm.nih.gov/pubmed/21356245
http://dx.doi.org/10.1016/j.antiviral.2011.02.008
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