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dsRNA binding characterization of full length recombinant wild type and mutants Zaire ebolavirus VP35

The Ebola viruses (EBOVs) VP35 protein is a multifunctional major virulence factor involved in EBOVs replication and evasion of the host immune system. EBOV VP35 is an essential component of the viral RNA polymerase, it is a key participant of the nucleocapsid assembly and it inhibits the innate imm...

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Detalles Bibliográficos
Autores principales: Zinzula, Luca, Esposito, Francesca, Pala, Daniela, Tramontano, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114247/
https://www.ncbi.nlm.nih.gov/pubmed/22289166
http://dx.doi.org/10.1016/j.antiviral.2012.01.005