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The viral RNA capping machinery as a target for antiviral drugs

Most viruses modify their genomic and mRNA 5′-ends with the addition of an RNA cap, allowing efficient mRNA translation, limiting degradation by cellular 5′–3′ exonucleases, and avoiding its recognition as foreign RNA by the host cell. Viral RNA caps can be synthesized or acquired through the use of...

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Detalles Bibliográficos
Autores principales: Ferron, François, Decroly, Etienne, Selisko, Barbara, Canard, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114304/
https://www.ncbi.nlm.nih.gov/pubmed/22841701
http://dx.doi.org/10.1016/j.antiviral.2012.07.007