Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors

The heptad repeats (HR1 and HR2) of the spike protein of SARS-CoV are highly conserved regions forming a critical 6-helix bundle during the fusion step of virus entry and are attractive targets of entry inhibitors. In this study, we report that a minimal HR2 peptide, P6 of 23-mer, can block the fusi...

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Detalles Bibliográficos
Autores principales: Liu, I-Jung, Kao, Chuan-Liang, Hsieh, Szu-Chia, Wey, Ming-Tsair, Kan, Lon-Sing, Wang, Wei-Kung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114320/
https://www.ncbi.nlm.nih.gov/pubmed/18983873
http://dx.doi.org/10.1016/j.antiviral.2008.10.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114320/
https://www.ncbi.nlm.nih.gov/pubmed/18983873
http://dx.doi.org/10.1016/j.antiviral.2008.10.001

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