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Characterization of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry

The spike (S) protein of human coronavirus NL63 (HCoV-NL63) mediates both cell attachment by binding to its receptor hACE2 and membrane fusion during virus entry. We have previously identified the receptor-binding domain (RBD) and residues important for RBD–hACE2 association. Here, we further charac...

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Detalles Bibliográficos
Autores principales: Lin, Han-Xin, Feng, Yan, Tu, Xinming, Zhao, Xuesen, Hsieh, Chih-Heng, Griffin, Lauren, Junop, Murray, Zhang, Chengsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114368/
https://www.ncbi.nlm.nih.gov/pubmed/21798295
http://dx.doi.org/10.1016/j.virusres.2011.06.029