Mutation in the cytoplasmic retrieval signal of porcine epidemic diarrhea virus spike (S) protein is responsible for enhanced fusion activity

Murine-adapted porcine epidemic diarrhea virus (PEDV), MK-p10, shows high neurovirulence and increased fusion activity compared with a non-adapted MK strain. MK-p10 S protein had four mutations relative to the original virus S, and one of these (H → R at position 1381, H1381R) in the cytoplasmic tai...

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Detalles Bibliográficos
Autores principales: Shirato, Kazuya, Maejima, Madoka, Matsuyama, Shutoku, Ujike, Makoto, Miyazaki, Ayako, Takeyama, Natsumi, Ikeda, Hidetoshi, Taguchi, Fumihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114372/
https://www.ncbi.nlm.nih.gov/pubmed/21840351
http://dx.doi.org/10.1016/j.virusres.2011.07.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114372/
https://www.ncbi.nlm.nih.gov/pubmed/21840351
http://dx.doi.org/10.1016/j.virusres.2011.07.019

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