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Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP

Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to cap their RNAs. In our previous work, the nonstructural protein (nsp) 14 of severe acute respiratory syndrome coronavirus (SARS-CoV) was identified as a cap (guanine-N7)-methyltransferase (N7...

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Detalles Bibliográficos
Autores principales: Jin, Xu, Chen, Yu, Sun, Ying, Zeng, Cong, Wang, Yi, Tao, Jiali, Wu, Andong, Yu, Xiao, Zhang, Zhou, Tian, Jie, Guo, Deyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114466/
https://www.ncbi.nlm.nih.gov/pubmed/23702198
http://dx.doi.org/10.1016/j.virusres.2013.05.001