Cargando…
Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP
Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to cap their RNAs. In our previous work, the nonstructural protein (nsp) 14 of severe acute respiratory syndrome coronavirus (SARS-CoV) was identified as a cap (guanine-N7)-methyltransferase (N7...
Autores principales: | Jin, Xu, Chen, Yu, Sun, Ying, Zeng, Cong, Wang, Yi, Tao, Jiali, Wu, Andong, Yu, Xiao, Zhang, Zhou, Tian, Jie, Guo, Deyin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114466/ https://www.ncbi.nlm.nih.gov/pubmed/23702198 http://dx.doi.org/10.1016/j.virusres.2013.05.001 |
Ejemplares similares
-
Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase
por: Sun, Ying, et al.
Publicado: (2014) -
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication
por: Ogando, Natacha S., et al.
Publicado: (2021) -
Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10/nsp16 complex
por: Ke, Min, et al.
Publicado: (2012) -
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase
por: Ahmed-Belkacem, Rostom, et al.
Publicado: (2020) -
Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases
por: Hausdorff, Marcel, et al.
Publicado: (2023)