Synthesis of a New Water-Soluble Melatonin Derivative with Low Toxicity and a Strong Effect on Sleep Aid

[Image: see text] A new melatonin sulfonate derivative sodium 4-(3-(2-acetamidoethyl)-5-methoxy-1H-indol-1-yl) butane-1-sulfonate (MLTBS) with higher water solubility (695 times) and lower cytotoxicity than natural melatonin (MLT) was synthesized, yet with the same sleep aid function. The poor solub...

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Detalles Bibliográficos
Autores principales: Zhang, Jianghong, Yan, Xu, Tian, Yunpeng, Li, Wanyun, Wang, Haiyang, Li, Qinbin, Li, Yufei, Li, Zhu, Wu, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114735/
https://www.ncbi.nlm.nih.gov/pubmed/32258885
http://dx.doi.org/10.1021/acsomega.9b04120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114735/
https://www.ncbi.nlm.nih.gov/pubmed/32258885
http://dx.doi.org/10.1021/acsomega.9b04120

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