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TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription
We present TADsplimer, the first computational tool to systematically detect topologically associating domain (TAD) splits and mergers across the genome between Hi-C samples. TADsplimer recaptures splits and mergers of TADs with high accuracy in simulation analyses and defines hundreds of TAD splits...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114812/ https://www.ncbi.nlm.nih.gov/pubmed/32241291 http://dx.doi.org/10.1186/s13059-020-01992-7 |