TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription

We present TADsplimer, the first computational tool to systematically detect topologically associating domain (TAD) splits and mergers across the genome between Hi-C samples. TADsplimer recaptures splits and mergers of TADs with high accuracy in simulation analyses and defines hundreds of TAD splits...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Guangyu, Meng, Qingshu, Xia, Bo, Zhang, Shuo, Lv, Jie, Zhao, Dongyu, Li, Yanqiang, Wang, Xin, Zhang, Lili, Cooke, John P., Cao, Qi, Chen, Kaifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114812/
https://www.ncbi.nlm.nih.gov/pubmed/32241291
http://dx.doi.org/10.1186/s13059-020-01992-7
Descripción
Sumario:We present TADsplimer, the first computational tool to systematically detect topologically associating domain (TAD) splits and mergers across the genome between Hi-C samples. TADsplimer recaptures splits and mergers of TADs with high accuracy in simulation analyses and defines hundreds of TAD splits and mergers between pairs of different cell types, such as endothelial cells and fibroblasts. Our work reveals a key role for TAD remodeling in epigenetic regulation of transcription and delivers the first tool for the community to perform dynamic analysis of TAD splits and mergers in numerous biological and disease models.

Ejemplares similares