TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription

We present TADsplimer, the first computational tool to systematically detect topologically associating domain (TAD) splits and mergers across the genome between Hi-C samples. TADsplimer recaptures splits and mergers of TADs with high accuracy in simulation analyses and defines hundreds of TAD splits...

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Detalles Bibliográficos
Autores principales: Wang, Guangyu, Meng, Qingshu, Xia, Bo, Zhang, Shuo, Lv, Jie, Zhao, Dongyu, Li, Yanqiang, Wang, Xin, Zhang, Lili, Cooke, John P., Cao, Qi, Chen, Kaifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114812/
https://www.ncbi.nlm.nih.gov/pubmed/32241291
http://dx.doi.org/10.1186/s13059-020-01992-7

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