Enhanced Bactericidal Effects of Pyrazinamide Toward Mycobacterium smegmatis and Mycobacterium tuberculosis upon Conjugation to a {Au(I)-triphenylphosphine}(+) Moiety

[Image: see text] As part of the quest for new gold drugs, we have explored the efficacy of three gold complexes derived from the tuberculosis drug pyrazinamide (PZA), namely, the gold(I) complex [Au(PPh(3))(PZA)]OTf (1, OTf = trifluoromethanesulfonate) and two gold(III) complexes [Au(PZA)Cl(2)] (2)...

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Detalles Bibliográficos
Autores principales: Stenger-Smith, Jenny, Kamariza, Mireille, Chakraborty, Indranil, Ouattara, Ramatoulaye, Bertozzi, Carolyn R., Mascharak, Pradip K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114878/
https://www.ncbi.nlm.nih.gov/pubmed/32258918
http://dx.doi.org/10.1021/acsomega.0c00071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114878/
https://www.ncbi.nlm.nih.gov/pubmed/32258918
http://dx.doi.org/10.1021/acsomega.0c00071

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