Amphiphilic Cationic Triscyclometalated Iridium(III) Complex–Peptide Hybrids Induce Paraptosis-like Cell Death of Cancer Cells via an Intracellular Ca(2+)-Dependent Pathway

[Image: see text] We report on the design and synthesis of a green-emitting iridium complex–peptide hybrid (IPH) 4, which has an electron-donating hydroxyacetic acid (glycolic acid) moiety between the Ir core and the peptide part. It was found that 4 is selectively cytotoxic against cancer cells, an...

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Detalles Bibliográficos
Autores principales: Yokoi, Kenta, Balachandran, Chandrasekar, Umezawa, Masakazu, Tsuchiya, Koji, Mitrić, Aleksandra, Aoki, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114882/
https://www.ncbi.nlm.nih.gov/pubmed/32258934
http://dx.doi.org/10.1021/acsomega.0c00337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114882/
https://www.ncbi.nlm.nih.gov/pubmed/32258934
http://dx.doi.org/10.1021/acsomega.0c00337

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